In the winter of 1850, a typhoid fever epidemic hit Jefferson College in Canonsburg, Pennsylvania. As many students left school to avoid the epidemic, William Henry Letterman and Charles Page Thomas Moore stayed to care for their classmates stricken with the disease. Letterman and Moore then decided to found a fraternity based on The Great Joy of Serving Others that they experienced during the epidemic.
On the night of February 19, 1852, Phi Kappa Psi was founded.